Integrative approach to HPA Axis Dysfunction (Adrenal Fatigue)
HPA axis dysregulation presents as fatigue, sleep disruption, mood instability, and poor stress resilience. While "adrenal fatigue" is not an ICD diagnosis, the clinical pattern of blunted cortisol rhythm is real and measurable.
Evidence highlight
Rhodiola rosea (400mg/day) significantly reduces burnout-related fatigue and cortisol awakening response dysregulation in clinical trials: Grade B evidence for HPA axis support.
Commonly used supplements
- Ashwagandha
- Rhodiola rosea
- Holy basil (Tulsi)
- Vitamin C
- Pantothenic acid (B5)
- Magnesium glycinate
- Licorice root
- Phosphatidylserine
Key interaction flags
Licorice root + antihypertensives or diuretics
Rhodiola + SSRIs (serotonergic risk)
Phosphatidylserine + anticoagulants
Ashwagandha + thyroid medications
Labs to consider
Clinical note
The 4-point salivary cortisol pattern determines the treatment plan direction. High evening cortisol needs phosphatidylserine. Low morning cortisol needs adaptogenic support. Treating without pattern data often produces inconsistent results.
Build a complete HPA Axis Dysfunction (Adrenal Fatigue) treatment plan with ClarityTX
Describe your patient's case. ClarityTX synthesizes from clinician-reviewed monographs and checks all drug-supplement interactions automatically.
Evidence-graded supplements
Every supplement recommendation for HPA Axis Dysfunction (Adrenal Fatigue) carries an A-D evidence grade with a link to the source. You see exactly what the evidence shows before you prescribe.
Automatic interaction checking
ClarityTX checks the full HPA Axis Dysfunction (Adrenal Fatigue) treatment plan against the patient's medication list. Severity rated: Contraindicated, Avoid, Monitor, or Caution.
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Switch to patient view: plain-language instructions, dosing schedule, and a 7-day meal plan. Export to PDF or share directly. Share only what care requires, and request a BAA before including patient information.
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Key supplements for HPA Axis Dysfunction (Adrenal Fatigue)
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