Clinical insights for integrative care
Research digests, interaction reviews, and practical perspectives on integrative clinical care.
The Hidden Risks in Supplement Recommendations: What Every Clinician Should Know
Patients arrive with self-assembled supplement stacks and strong opinions about what they need. Understanding where interaction risk hides — and how to review it efficiently — is one of the more important skills in integrative practice.
Drug-Supplement Interactions Every Functional Medicine Practitioner Should Know
Patients often arrive with prescriptions from multiple specialists plus self-directed supplement stacks. Here is why interaction screening, CYP450 review, and evidence-graded protocols belong inside every functional medicine workflow.
How to Create a Patient-Ready Protocol Without a Staff of Researchers
Small integrative practices can't afford hours of after-hours research per patient. Here's how to build evidence-based, personalized protocols that patients can actually follow -- without a full research team behind you.
Not All Clinical AI Is the Same: What Integrative Clinicians Should Look for in AI Tools
General-purpose AI was not designed for integrative medicine. Knowing what to look for -- reviewed sources, interaction checking, evidence grading -- separates tools that help from tools that create new risks.
Urolithin A: Why Your Patient's Gut Microbiome Determines Whether Pomegranate Works
Urolithin A induces mitophagy via the PINK1/Parkin pathway — but only ~40% of people can produce it from dietary ellagitannins. The Phase 2 RCT shows what supplemental UA does to mitochondrial function in skeletal muscle, regardless of microbiome status.
Spermidine: The Autophagy Inducer That Declines With Age
Serum spermidine falls ~50% between age 20 and 80. New evidence links dietary and supplemental spermidine to autophagy induction, cardiovascular protection, and memory preservation — through a mechanism entirely independent of mTOR.
Berberine vs. Metformin: What the Evidence Actually Says
Multiple RCTs show berberine matches metformin on HbA1c reduction in T2DM. Here is what the trials looked like, where the gaps are, and how to think about it at the point of care.
Low-Dose Naltrexone: The Off-Label Use the Evidence Is Finally Catching Up To
At 1 to 4.5mg per day, naltrexone does something pharmacologically distinct from its standard addiction-medicine dose. Growing evidence supports its use in fibromyalgia, Crohn's disease, and MS via a non-opioid neuroinflammatory mechanism.
Akkermansia muciniphila: The Gut Bacterium Rewriting Metabolic Medicine
Akkermansia muciniphila inversely correlates with obesity, T2DM, and metabolic syndrome in virtually every human cohort studied. The first human RCTs show what supplementation actually does — and why the mechanism matters for integrative protocols.
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