Integrative approach to Fibromyalgia
Fibromyalgia involves central sensitization, mitochondrial dysfunction, and often overlapping conditions including IBS, sleep disorders, and mood dysregulation. Integrative treatment plans address multiple root causes simultaneously.
Evidence highlight
Magnesium malate (300-600mg elemental magnesium/day) reduces tender point pain and fatigue scores in fibromyalgia: Grade B evidence across 3 clinical trials.
Commonly used supplements
- Magnesium malate
- CoQ10
- D-ribose
- Low-dose naltrexone (LDN)
- SAMe
- Vitamin D
- 5-HTP
- Malic acid
Key interaction flags
5-HTP + SSRIs/SNRIs (serotonin syndrome risk)
SAMe + antidepressants
LDN + opioid medications (contraindicated)
Labs to consider
Clinical note
LDN (1.5-4.5mg) has emerging evidence for fibromyalgia via glial modulation and neuroinflammation reduction. It is one of the few integrative interventions with a plausible mechanism for central sensitization directly.
Build a complete Fibromyalgia treatment plan with ClarityTX
Describe your patient's case. ClarityTX synthesizes from clinician-reviewed monographs and checks all drug-supplement interactions automatically.
Evidence-graded supplements
Every supplement recommendation for Fibromyalgia carries an A-D evidence grade with a link to the source. You see exactly what the evidence shows before you prescribe.
Automatic interaction checking
ClarityTX checks the full Fibromyalgia treatment plan against the patient's medication list. Severity rated: Contraindicated, Avoid, Monitor, or Caution.
Patient-ready in one click
Switch to patient view: plain-language instructions, dosing schedule, and a 7-day meal plan. Export to PDF or share directly. Share only what care requires, and request a BAA before including patient information.
Your first Fibromyalgia treatment plan is free
7 days, 10 questions and 1 treatment plan, with no credit card. Start with a clinical question, review the evidence, and build a full treatment plan when needed.
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Key supplements for Fibromyalgia
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