Integrative approach to Migraine
Migraine affects 15% of the population and is significantly undertreated. Integrative approaches address mitochondrial dysfunction, magnesium deficiency, neuroinflammation, and hormonal triggers, reducing frequency and severity alongside conventional prophylaxis.
Evidence highlight
Magnesium (400-600mg/day) reduces migraine frequency by 41% vs 15% placebo in double-blind RCT: Grade A prophylactic evidence. Up to 50% of migraine patients have interictal magnesium deficiency undetectable by serum testing.
Commonly used supplements
- Magnesium glycinate
- Riboflavin (B2)
- CoQ10 (ubiquinol)
- Butterbur (PA-free)
- Feverfew
- Melatonin
- Omega-3s
- 5-HTP
Key interaction flags
Butterbur + hepatotoxic medications (monitor LFTs)
5-HTP + triptans or SSRIs (serotonin syndrome risk)
Feverfew + anticoagulants
High-dose riboflavin + certain chemotherapy agents
Labs to consider
Clinical note
RBC magnesium is the only reliable test for intracellular magnesium status: serum magnesium is normal even in deficiency. Migraine prophylaxis with riboflavin (400mg/day) + CoQ10 (300mg/day) + magnesium has additive benefit and is supported by the Canadian Headache Society.
Build a complete Migraine treatment plan with ClarityTX
Describe your patient's case. ClarityTX synthesizes from clinician-reviewed monographs and checks all drug-supplement interactions automatically.
Evidence-graded supplements
Every supplement recommendation for Migraine carries an A-D evidence grade with a link to the source. You see exactly what the evidence shows before you prescribe.
Automatic interaction checking
ClarityTX checks the full Migraine treatment plan against the patient's medication list. Severity rated: Contraindicated, Avoid, Monitor, or Caution.
Patient-ready in one click
Switch to patient view: plain-language instructions, dosing schedule, and a 7-day meal plan. Export to PDF or share directly. Share only what care requires, and request a BAA before including patient information.
Your first Migraine treatment plan is free
7 days, 10 questions and 1 treatment plan, with no credit card. Start with a clinical question, review the evidence, and build a full treatment plan when needed.
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Key supplements for Migraine
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